Yuito: His father and best friend died in his arms
Kasane: Lost her sister, disowned by her adoptive parents AND lost her mother
Tsugumi: Alienated as a child, raised by her grandfather, her only friends were plants for years
Kyoka: Had to live and work with the fear of death
Kagero: Forced into cold sleep for 2000 years and didnt get the chance to watch his daughter grow
Hanabi: Got a bad reputation due to her father's shady work in the OSF hospital
Arashi: Also got a bad name from Spring Pharmaceuticals
Luka: Was a dud and treated like a lab experiment
Shiden: Just wanted to be recognised
Gemma: Watched many new recruits die in his platoons, also badly affected by Naomi's death